OPEN POSITIONS

Postdoc Position in Biofilm Mechanics & Antibiotic Resistance
Project: Mechanoregulation of Klebsiella pneumoniae biofilm antibiotic tolerance

We are seeking a postdoc with a strong interest in bridging biophysics and infection biology to investigate the mechanobiology of the pathogen Klebsiella pneumoniae. K. pneumoniae has emerged as a top-priority antibiotic-resistant pathogen, driven by the rapid global spread of hypervirulent and carbapenem-resistant strains. Its biofilms play central roles in immune evasion and treatment failure, yet their mechanics remain poorly understood. This project addresses this gap by uncovering how these material properties promote resilience and antibiotic tolerance.
In this project, you will develop experimental and analytical approaches to quantify the mechanics of K. pneumoniae cells and biofilms, and link their mechanical properties to antibiotic response and organoid colonization.

We welcome applicants from biophysics, bioengineering, soft-matter physics, microbiology or related disciplines. A solid quantitative background (microfluidics, mechanics, imaging, data analysis) and a motivation to work at the interface of biology, physics, and engineering are both required. You will join a dynamic, international lab specializing in bacterial mechanobiology, microfluidic organoid infection models, and high-resolution live imaging. The project is part of a broader program integrating mechanical, genetic, and infection biology approaches to understand how K. pneumoniae withstands antibiotics and interacts with host tissues.

To apply, fill up information in this form.

Spontaneous applications
Anyone motivated by our research is welcome to apply spontaneously. To apply, submit CV, cover letter and contact information of three references to alexandre.persat@epfl.ch.

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